[Expression of CD44V6 and nm23-H1 in thyroid papillary adenocarcinoma and lymph node metastasis]

Expression of CD44V6 and nm23-H1 in thyroid papillary adenocarcinoma (TPC) was studied in 84 patients by immunohistochemistry. The positive rates of CD44V6 and nm23-H1 were 63.1% and 48.8% respectively. An increased CD44V6 and a decreased nm23-H1 positive rate in patients with lymph node metastasis (LNM) were observed (P < 0.01). Negative correlation was existed between overexpression of CD44V6 and low-expression of nm23-H1 (P < 0.01). The results suggested that CD44V6 and nm23-H1 play important role in LNM of TPC and disordered expression of CD44V6 and nm23-H1 are involved in the process of LNM.