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Updated: Jul 9, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Meconium-stained amniotic fluid and intra-amniotic infection]
Pi-Xiang Pi1, Fu-Fan Zhu, Jian Huang
1Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Objective:
To explore the relationship between meconium-stained amniotic fluid and Fifty-six women of cesarean section with intact membrane and intra-amniotic infection.
Methods:
without parturient were divided into 3 groups according to the property of amniotic fluid (no meconium, I to approximately II degree meconium stainedness, and III degree mecomium stainedness). The content of interleukin-6 in amniotic fluid was measured with ELISA. The infiltration of inflammatory cells in the placenta and its membrane was determined by the pathological diagnosis. The neonatal Apgar score and puerperial infection after the surgery were analyzed.
Results:
There were no significant differences in the content of IL-6 in amniotic fluid and in the infiltration of inflammatory cells among the 3 groups. But the rate of neonatal asphyxia in the meconium-stained cases was significantly higher than that without meconium.
Conclusion:
Meconium-stained amniotic fluid is a marker of fetal distress, but it is not related to intra-amniotic infection.
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