[Experimental study of FZBZ decoction enhancing chemotherapy efficacy for mice bearing with tumors]

To study the mechanism of the increasing effect of Fuzheng Baozhen decoction (FZBZD) on chemotherapy. The BALB/C mice with transplanted human lung adenocarcinoma (SPC-A-1), sarcoma (S180) were treated in different groups. Comparing the group treated with chemotherapy (CTX), and the group treated with CTX plus FZBZD, the inhibiting tumor rate was higher (P < 0.01), the cAMP/cGMP ratio was increased by adding cAMP level in cancer tissue (P < 0.05), the level of serum TNF-alpha and MDA was decreased (P < 0.01), the activity of total SOD was improved (P < 0.01), the G0/G1 phase cells enhanced and S phase cells decreased in tumor tissue (P < 0.05). It suggested that FZBZD increased the effect of chemotherapy in different ways.