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Updated: Oct 17, 2026

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
[Optimazation of conditions for stereoselective reaction by enzyme-catalyzed acetylation]
Abstract:
Optically active endo-tricyclo-[5,2,1, 0(2,6)]deca-8-en-3,5-diol-5-acetate is a very useful chiral synthon for the synthesis of optically active natural products. In this paper, the optimal conditions for the synthesis of this compound was established by orthogonality test. Under these conditions, the chemical percentage yield of acetylation of (+) endo-tricyclo-[5,2,1,0(2,6)] deca-8-en-3,5-diol-5-acetate and its % e.e. can reach up to 81% and 98.3% respectively. The optimazation of the conditions is efficient for the reaction of enzyme-catalyzed esterification.
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