[A comparison study on the sensitivity of lung tumor short-term induction test in three strains of mice]

To compare the sensitivities of lung tumor short-term induction in different strains of mice, the carcinogenicity risk was evaluated with the incidence rate and the average number of tumors. Three different strains of mice (KM, BALB/c and A/J) were injected with a single different dose of urethane i.p. The results demonstrated that the lowest dose for increasing tumor risk was 100 mg/kg in KM, 200 mg/kg in BALB/c, and lower than 25 mg/kg in A/J strain. So, the sensitivity of A/J strain is the highest and that of BALB/c is the lowest.