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Antiphospholipid antibodies and in vitro fertilization success: a meta-analysis
M D Hornstein1, O K Davis, J B Massey
1Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. mdhornstei@bics.bwh.harvard.edu
Objective:
To evaluate whether the presence of antiphospholipid antibodies among women undergoing IVF affects the likelihood of IVF success.
Design:
A meta-analysis of seven eligible studies on antiphospholipid antibodies and IVF outcome.
Main Outcome Measure(S):
Odds ratios (ORs) and 95% confidence intervals (CIs) of an association between the presence of antiphospholipid antibodies and both clinical pregnancy and live birth from IVF.
Result(S):
There was no significant association between antiphospholipid abnormalities and either clinical pregnancy (OR 0.99; 95% CI 0.64-1.53) or live birth (OR 1.07; 95% CI 0.66-1.75) in IVF patients.
Conclusion(S):
The measurement of antiphospholipid antibodies is not warranted in patients undergoing IVF.
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