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Updated: Aug 16, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
Laboratory effectiveness of different types of fluoride compounds
Abstract:
The enamel solubility reducing characteristics of four fluorides -- sodium fluoride (NaF), acidulated phosphate fluoride (APF), stannous fluoride (SnF2), and sodium monofluorophosphate (Na2PO3F), each prepared to contain 1.23 per cent F are evaluated. Initial solubility reduction by SnF2, 81.7 per cent was significantly (P less than .01) higher than that of 76.9 per cent provided by APF, however, after repeated exposure to acid etches the protection by APF became significantly (P less than .01) higher than that derived from SnF2. The durability of protection provided by SnF2 after overnight washing, was significantly (P less than .01) higher than that of APF. Results for NaF and MFP were significantly (P less than .01) lower than those of either APF or SnF2 at any point in the experiment.
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