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Related Experiment Videos

Evaluation of inner ear histology and auditory brainstem response in Wriggle Mouse Sagami.

K Takahashi1, N Osawa, M Ohmura

  • 1Department of Otolaryngology, Jichi Medical School, Minamikawachi, Tochigi, Japan. takamasa@jichi.ac.jp

Acta Oto-Laryngologica
|February 25, 2000
PubMed
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The Wriggle Mouse Sagami (WMS) model exhibits progressive inner ear degeneration, leading to deafness in homozygous and heterozygous mice. This mouse strain offers a valuable tool for studying human deafness genes.

Area of Science:

  • Genetics
  • Neuroscience
  • Otolaryngology

Background:

  • Wriggle Mouse Sagami (WMS) is a spontaneous mutant mouse strain.
  • WMS mice display neuroepithelial defects and abnormal movements due to an autosomal recessive gene.

Purpose of the Study:

  • To investigate the relationship between inner ear histology and hearing impairment in WMS mice.
  • To characterize the progression of auditory deficits in WMS mice.

Main Methods:

  • Histological examination of the cochlea and saccule in homozygous, heterozygous, and wild-type mice.
  • Auditory brainstem evoked response (ABR) testing to assess hearing ability across different frequencies and ages.

Main Results:

  • Homozygous WMS mice showed cochlear and saccular degeneration by 3 months, with organ of Corti and spiral ganglion cell loss.

Related Experiment Videos

  • Heterozygous WMS mice exhibited cochlear degeneration but not saccular degeneration.
  • Auditory brainstem evoked response testing revealed complete deafness in homozygotes from 1 month and in heterozygotes after 1 month of age.

    • Conclusions:

    • WMS mice present a progressive inner ear degeneration model.
    • This model is suitable for identifying genes associated with human deafness.
    • The study highlights the utility of WMS mice in auditory research.