Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacterial cell division.

L Rothfield1, S Justice, J García-Lara

  • 1Department of Microbiology, University of Connecticut Health Center, Farmington 06032, USA. lroth@panda.uchc.edu

Annual Review of Genetics
|February 26, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Faecal immunochemical testing (FIT): sources of result variation based on three years of routine testing of symptomatic patients in English primary care.

British journal of biomedical science·2021
Same author

Incidence, predictors, and effects of acute kidney injury after percutaneous valve implantation.

The Journal of invasive cardiology·2014
Same author

Estimation ofEscherichia coli mortality in seawater by the decrease in(3)H-label and electron transport system activity.

Microbial ecology·2013
Same author

Dissociation and reassociation of bacterial membrane components.

The Journal of general physiology·2009
Same author

Independent predictors of renal dysfunction after heart transplantation in patients with normal pretransplant renal function.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2005
Same author

The role of genomics in approaching the study of Borrelia DNA replication.

Journal of molecular microbiology and biotechnology·2000
Same journal

Genomic Imprinting: Common Threads Uniting Diverse Biological Systems.

Annual review of genetics·2026
Same journal

Properties and Prospects of B Chromosomes.

Annual review of genetics·2026
Same journal

Lessons From Yeast: Mechanisms of Telomere Length Regulation.

Annual review of genetics·2026
Same journal

Mechanisms and Evolutionary Advantages of Unlimited Reproductive Lifespans in Naked Mole-Rat Queens.

Annual review of genetics·2026
Same journal

Impact of Small RNA Sponges on Regulatory RNA Networks in Bacteria.

Annual review of genetics·2025
Same journal

Context Specificity of MAP3K DLK Signaling in the Nervous System: Insights from Genetics and Genomics.

Annual review of genetics·2025
See all related articles

Bacterial cell division involves proteins forming a ring, guided by FtsZ, MinC, and MinE. The precise placement of this division site and its coordination with DNA replication remain areas for further research.

Area of Science:

  • Microbiology
  • Cell Biology
  • Molecular Biology

Background:

  • Bacterial septum formation is essential for cell division and relies on protein assembly into a cytokinetic ring.
  • The FtsZ protein initiates ring assembly, analogous to eukaryotic tubulins.
  • Accurate division site placement in Escherichia coli involves the MinC division inhibitor and the MinE topological specificity protein.

Purpose of the Study:

  • To elucidate the mechanisms of bacterial division site placement.
  • To understand the coordination between cell division and other cell cycle events like chromosome replication.
  • To investigate the role of specific proteins in regulating these processes.

Main Methods:

  • The study focuses on the known proteins involved in bacterial cytokinesis, including FtsZ, MinC, and MinE.

Related Experiment Videos

  • It reviews existing knowledge on division site selection and regulation.
  • It highlights the identification of the CtrA protein in Caulobacter as a key regulator.

    • Main Results:

    • The hierarchical assembly of the cytokinetic ring is initiated by FtsZ.
    • MinC and MinE are crucial for preventing division at cell poles and ensuring midcell septation in E. coli.
    • The exact mechanisms for site identification and coordination with DNA replication are not fully understood.
    • CtrA in Caulobacter regulates both chromosome replication initiation and ftsZ transcription.

    Conclusions:

    • While FtsZ, MinC, and MinE are key players in bacterial division site placement, the precise mechanisms are still under investigation.
    • The coordination of cell division with DNA replication is complex and involves regulatory proteins like CtrA.
    • Further research is needed to fully understand these regulatory networks and their implications for bacterial cell cycle control.