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Related Experiment Videos

Barriers in the immature brain.

N R Saunders1, G W Knott, K M Dziegielewska

  • 1University of Tasmania, Australia. N.Saunders@utas.edu.au

Cellular and Molecular Neurobiology
|February 26, 2000
PubMed
Summary
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The blood-brain barrier and blood-cerebrospinal fluid barrier mature during development, reducing permeability. Tight junctions in endothelial and epithelial cells are key morphological features that develop over time.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Physiology

Background:

  • The blood-brain barrier (BBB) regulates molecular exchange between the brain and body.
  • Tight junctions between cerebral endothelial and choroid plexus cells form the BBB's morphological basis.
  • These junctions are present early but mature during brain development.

Purpose of the Study:

  • To describe the mechanisms controlling molecular exchange in the brain.
  • To detail the morphological features of brain barriers and their developmental changes.
  • To explain the developmental decline in brain barrier permeability.

Main Methods:

  • Review of existing literature on brain barrier development.
  • Analysis of morphological features, including tight junctions and intercellular specializations.

Related Experiment Videos

  • Examination of permeability changes to various molecules during development.

    • Main Results:

    • Tight junctions are crucial for restricting protein entry into the brain.
    • Immature brains have additional barriers (strap junctions) at CSF-brain interfaces that disappear in adults.
    • Permeability to small, lipid-insoluble compounds decreases with BBB and blood-cerebrospinal fluid interface maturation.

    Conclusions:

    • Brain barrier development involves maturation of tight junctions and loss of transient barriers.
    • These developmental changes lead to reduced permeability in the mature brain.
    • Understanding BBB development is crucial for studying brain physiology and disease.