Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurophysiological aspects of pattern-sensitive epilepsy.

A J Wilkins, C E Darby, C D Binnie

    Brain : a Journal of Neurology
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The possible use of precision tinted lenses to improve social cognition in children with autism spectrum disorders.

    Vision research·2020
    Same author

    Chromaticity separation and the alpha response.

    Neuropsychologia·2017
    Same author

    Cortical excitability and the shape of the haemodynamic response.

    NeuroImage·2015
    Same author

    Assessment and selection of candidates for surgical treatment of epilepsy.

    Epilepsia·2012
    Same author

    Electroencephalography today.

    Journal of the Royal Society of Medicine·2010
    Same author

    Spectral filters can improve reading and visual search in patients with multiple sclerosis.

    Journal of neurology·2007
    Same journal

    SMPD4 deficiency disrupts indirect neurogenesis and neuronal migration in gyrencephalic cortex.

    Brain : a journal of neurology·2026
    Same journal

    Retinal hyper-reflective foci link retinal and cortical pathology in paediatric multiple sclerosis.

    Brain : a journal of neurology·2026
    Same journal

    Two scripts, two pathways: dorsal-ventral biases in post-stroke kana-kanji agraphia.

    Brain : a journal of neurology·2026
    Same journal

    Blood cytotoxic natural killer-like CD8 + CD94+ T cells migrate to the brain and predict multiple sclerosis severity.

    Brain : a journal of neurology·2026
    Same journal

    Time to reconsider risk for psychosis?

    Brain : a journal of neurology·2026
    Same journal

    A descending posterior insular pathway drives sensory hypersensitivity in neuropathic pain.

    Brain : a journal of neurology·2026
    See all related articles

    Pattern-sensitive epilepsy patients experience seizures triggered by visual stimuli. Seizure risk depends on pattern spatial frequency, orientation, contrast, and size, suggesting a striate cortex origin.

    Area of Science:

    • Neuroscience
    • Epileptology
    • Visual Neuroscience

    Background:

    • Pattern sensitivity is a key feature in some epilepsy cases.
    • Understanding visual triggers is crucial for managing pattern-sensitive epilepsy.

    Purpose of the Study:

    • To investigate the specific visual parameters of striped patterns that induce paroxysmal electroencephalogram (EEG) activity in pattern-sensitive epilepsy patients.
    • To determine the neural origin of seizure triggers in the visual pathway.

    Main Methods:

    • Patients with pattern-sensitive epilepsy were exposed to square-wave gratings with varying spatial frequencies, orientations, brightness contrasts, and sizes.
    • Electroencephalogram (EEG) activity was recorded to measure paroxysmal responses.
    • Investigated responses to isoluminant red/green gratings and diffuse flickering fields.

    Related Experiment Videos

    Main Results:

    • Optimal spatial frequency for inducing EEG activity was 1-4 cycles/degree.
    • Increased brightness contrast significantly elevated seizure probability.
    • Individual patients exhibited orientation selectivity, but no single orientation was universally more potent.
    • Pattern size influenced seizure probability, with a twofold increase in angular subtense doubling the probability.
    • Patterns stimulating multiple orientation systems were less epileptogenic.
    • Isoluminant gratings and diffuse flickering fields provided further evidence against thalamic involvement.

    Conclusions:

    • The findings support a seizure trigger located in the striate cortex, not the lateral geniculate nucleus.
    • Visual parameters like spatial frequency, contrast, and size are critical in modulating seizure susceptibility in pattern-sensitive epilepsy.
    • Binocular mechanisms are implicated in flicker-induced responses.