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Related Experiment Videos

Neonatal thyroxine level and perchlorate in drinking water.

Z Li1, F X Li, D Byrd

  • 1Epidemiology and Occupational Health, Inc., Washington, DC 20007, USA.

Journal of Occupational and Environmental Medicine
|February 29, 2000
PubMed
Summary

Newborn thyroid function was not affected by perchlorate in drinking water. This study found no difference in thyroxine (T4) levels in infants from Las Vegas, where perchlorate is present, compared to Reno, Nevada.

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Area of Science:

  • Environmental Health
  • Endocrinology
  • Pediatric Health

Background:

  • Perchlorate contamination in drinking water is an environmental concern.
  • Perchlorate is known to interfere with thyroid function.
  • The impact of perchlorate exposure on neonatal thyroid health requires investigation.

Purpose of the Study:

  • To assess the effect of environmental perchlorate exposure on neonatal thyroid function.
  • To compare thyroxine (T4) levels in newborns from areas with and without perchlorate in drinking water.

Main Methods:

  • A comparative study analyzing neonatal blood thyroxine (T4) levels in newborns from Las Vegas, Nevada (perchlorate present) and Reno, Nevada (perchlorate absent).
  • Blood samples were collected during the first 4 days of life for over 23,000 newborns between April 1998 and June 1999.

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  • Drinking water perchlorate levels in Las Vegas were monitored monthly during the study period.

    • Main Results:

    • No significant difference was observed in mean blood T4 levels between newborns from Las Vegas and Reno.
    • Perchlorate levels in Las Vegas drinking water varied, ranging from non-detectable to 15 ppb during the study.
    • While temporal variations in T4 levels were noted in both cities, they were not linked to perchlorate exposure.

    Conclusions:

    • Environmental exposure to perchlorate in drinking water, up to 15 ppb, did not demonstrate an effect on neonatal thyroid function in the studied population.
    • The study was sensitive enough to detect influences of gender, birth weight, and infant age on T4 levels, but not perchlorate exposure.
    • Findings suggest that current levels of perchlorate in Las Vegas drinking water did not impact newborn thyroid hormone levels during the study period.