Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Manipulating the metabolic response to injury.

R D Griffiths1, C J Hinds, R A Little

  • 1Department of Medicine, University of Liverpool, UK.

British Medical Bulletin
|March 1, 2000
PubMed
Summary

This review focuses on muscle wasting, a key feature of the metabolic response to injury, known as the

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new method for the high-precision assessment of tumor changes in response to treatment.

Bioinformatics (Oxford, England)·2018
Same author

Reply to letter on "Improving rehabilitation following critical illness through outpatient physiotherapy classes and essential amino acid supplement: A randomised, controlled trial".

Journal of critical care·2015
Same author

Improving rehabilitation after critical illness through outpatient physiotherapy classes and essential amino acid supplement: A randomized controlled trial.

Journal of critical care·2015
Same author

Dynamic preload markers to predict fluid responsiveness during and after major gastrointestinal surgery: an observational substudy of the OPTIMISE trial.

British journal of anaesthesia·2014
Same author

Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort.

Intensive care medicine·2013
Same author

Mental and physical disability after sepsis.

Minerva anestesiologica·2013

Area of Science:

  • Metabolic response to injury
  • Physiology
  • Trauma and critical care

Background:

  • The metabolic response to injury, or 'flow' phase, involves hypermetabolism, insulin resistance, and muscle wasting.
  • These interconnected features significantly impact patient recovery and outcomes.
  • Understanding muscle wasting is crucial for managing critically ill patients.

Purpose of the Study:

  • To review the phenomenon of muscle wasting (catabolism) during the metabolic 'flow' phase following injury.
  • To highlight the interrelationship between muscle wasting and other metabolic responses like hypermetabolism and insulin resistance.
  • To provide a focused overview of muscle wasting in the context of trauma, injury, or sepsis.

Main Methods:

  • Literature review focusing on muscle wasting in the metabolic response to injury.
  • Analysis of the interrelations between catabolism, hypermetabolism, and insulin resistance.
  • Synthesis of current understanding regarding muscle wasting during the 'flow' phase.

Main Results:

  • Muscle wasting is a significant component of the metabolic response to injury.
  • Interventions like temperature modulation can impact protein catabolism markers.
  • Insulin plays a role in regulating amino acid flux in skeletal muscle.

Conclusions:

  • Muscle wasting is a critical aspect of the metabolic response to injury.
  • Further research into managing muscle catabolism is warranted.
  • This review provides a focused perspective on muscle wasting, complementing existing literature on insulin resistance and metabolic rate.

Related Experiment Videos