Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HRT and cardiovascular disease.

T W Meade1, M R Vickers

  • 1MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, London, UK.

Journal of Epidemiology and Biostatistics
|March 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Northwick Park Heart Studies: contrasts between the two factor VII assays used.

Journal of thrombosis and haemostasis : JTH·2012
Same author

Circulating markers of arterial thrombosis and late-stage age-related macular degeneration: a case-control study.

Eye (London, England)·2010
Same author

Systematically missing confounders in individual participant data meta-analysis of observational cohort studies.

Statistics in medicine·2009
Same author

Assessing the contribution of fibrinogen in predicting risk of death in men with peripheral arterial disease.

Journal of thrombosis and haemostasis : JTH·2008
Same author

The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases.

European journal of epidemiology·2007
Same author

Biphasic immunomodulating effect of cephalosporin derivatives in man in vitro and in vivo.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2007
Same journal

Agreement between general practice prescription data and self-reported use of hormone replacement therapy and treatment for various illnesses.

Journal of epidemiology and biostatistics·2002
Same journal

A piecewise-homogeneous Markov chain process of lung transplantation.

Journal of epidemiology and biostatistics·2002
Same journal

Determining and visualising at-risk groups in case-control data.

Journal of epidemiology and biostatistics·2002
Same journal

Distribution of family history of a disease as a function of mode of inheritance, genetic relative hazard, allele frequency and disease status of the proband, with application to female breast cancer.

Journal of epidemiology and biostatistics·2002
Same journal

Changes and trends in attack distributions and progression of dental caries in three age cohorts in Finland.

Journal of epidemiology and biostatistics·2002
Same journal

A loss-function based approach for dose selection in two-stage dose-response trials.

Journal of epidemiology and biostatistics·2002
See all related articles

Hormone replacement therapy (HRT) effects on cardiovascular disease remain uncertain. Recent studies suggest HRT neither harms nor protects against coronary heart disease, necessitating further randomized controlled trials for clarity.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Clinical Trials

Background:

  • Clinical decisions regarding hormone replacement therapy (HRT) and cardiovascular disease (CVD) have evolved significantly over three decades.
  • Early assumptions of HRT increasing thromboembolic conditions were challenged by studies in the 1980s suggesting cardioprotective effects.
  • Recent findings, including the Heart and Estrogen/progestin Replacement Study (HERS), indicate HRT has a neutral effect on coronary heart disease (CHD) incidence.

Purpose of the Study:

  • To address the conflicting evidence and decision-making challenges surrounding long-term HRT use for cardiovascular health.
  • To highlight the need for definitive data to guide clinical practice and patient choices regarding HRT.

Main Methods:

  • Review of historical assumptions and findings related to HRT and cardiovascular outcomes.

Related Experiment Videos

  • Analysis of recent study data, such as the HERS trial, on HRT's impact on CHD.
  • Emphasis on the role of randomized controlled trials (RCTs) in establishing evidence-based conclusions.

    • Main Results:

    • Historical perspectives show a shift from HRT increasing to potentially decreasing CVD risk.
    • The HERS trial suggests HRT does not significantly alter the incidence of coronary heart disease.
    • Current evidence presents a complex and often contradictory picture of HRT's cardiovascular effects.

    Conclusions:

    • The fluctuating conclusions on HRT's cardiovascular effects create significant clinical uncertainty.
    • Further large-scale, randomized controlled trials are essential to provide stable, reliable evidence.
    • Establishing clear guidelines based on robust RCT data is crucial for informed clinical decisions on HRT.