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[Chronic eosinophilic meningoencephalitis due to Candida guillermondii]

L Paz-Sendín1, R González-Torres, L Gámez-Morales

  • 1Servicio de Neurología, Hospital Carlos J. Finlay, La Habana, Cuba.

Revista De Neurologia
|March 4, 2000
PubMed
Abstract

Insights

Chronic eosinophilic meningoencephalitis, a condition with persistent eosinophils in cerebrospinal fluid (CSF), can be caused by the fungus Candida guillermondii. This fungal infection is treatable, leading to complete neurological recovery.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Mycology

Background:

  • Eosinophilic meningoencephalitis presents with meningeal syndrome and eosinophilic cerebrospinal fluid (CSF).
  • Chronic meningoencephalitis, persisting over four weeks, has diverse etiologies, including fungal infections.
  • Fungal infections are a recognized cause of chronic meningoencephalitis.

Observation:

  • A patient presented with chronic meningoencephalitis, marked by persistent eosinophils in CSF.
  • Symptoms included severe headache, mild neck stiffness, focal motor deficits, and signs of intracranial hypertension.
  • CSF analysis revealed Candida guillermondii.

Findings:

  • Candida guillermondii was identified as the causative agent in a case of chronic eosinophilic meningoencephalitis.
  • Antifungal treatment with amphotericin B led to complete resolution of the neurological disorder.
  • This case highlights a specific fungal etiology for chronic eosinophilic meningoencephalitis.

Implications:

  • Candida guillermondii should be considered in the differential diagnosis of chronic eosinophilic meningoencephalitis.
  • Prompt diagnosis and appropriate antifungal therapy are crucial for favorable outcomes.
  • This finding expands the known spectrum of fungal pathogens implicated in central nervous system infections.

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