Transforming growth factor beta 1 (TGF beta 1) down-regulates expression and function of proliferation-inducing

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Updated: Oct 17, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

M K Shier1, E B Neely, M G Ward

  • 1Department of Microbiology and Immunology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033, USA.

Anticancer Research
|March 4, 2000
PubMed

Insights

Transforming growth factor beta 1 (TGF beta 1) may inhibit human papillomavirus (HPV)-driven cell growth by reducing key proliferation molecules like bcl-2 and NFkB in some HPV-transformed cells.

Area of Science:

  • Oncology
  • Virology
  • Cell Biology

Background:

  • Human papillomavirus (HPV) infection is linked to cervical dysplasia and cancer.
  • Transforming growth factor beta 1 (TGF beta 1) inhibits epithelial cell growth.
  • Previous research indicated TGF beta 1 induction and growth stimulatory molecule downregulation in experimental papillomas.

Purpose of the Study:

  • To investigate the phenotype of HPV-transformed cells.
  • To examine the expression of TGF beta 1 and its regulation of proliferation-enhancing molecules (bcl-2, c-jun, NFkB).

Main Methods:

  • Utilized HPV-16 and HPV-18 transformed cell lines.
  • Assessed expression of TGF beta 1, bcl-2, c-jun, and NFkB.
  • Evaluated NFkB function following TGF beta 1 treatment.

Main Results:

  • HPV-16 transformed cells exhibited TGF beta 1-induced downregulation of bcl-2 and NFkB.
  • NFkB function was also reduced in HPV-16 cells upon TGF beta 1 treatment.

Conclusions:

  • TGF beta 1 may exert antiproliferative effects on certain HPV-transformed cells.
  • This effect is achieved by downregulating key proliferation-enhancing molecules.
  • Further research is needed to determine if this is virus type-specific or related to tumor progression stage.

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