Related Experiment Video
Updated: Aug 14, 2026
19:57
An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
Delaying antimalarial drug resistance with combination chemotherapy
1Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. fnnjw@gold.diamond.mahidol.ac.th
Parassitologia
|March 4, 2000
Summary
To prevent malaria drug resistance, use multiple antimalarials together. Combining artemisinin derivatives with other drugs is effective, as no resistance to artemisinin has been reported.
Area of Science:
- Tropical Medicine
- Parasitology
- Pharmacology
Background:
- Antimalarial drug resistance is a major threat to malaria control.
- Resistance emerges through genetic mutations selected by drug pressure.
- Simultaneous drug use with different mechanisms reduces resistance selection probability.
Purpose of the Study:
- To evaluate the potential of artemisinin derivatives as combination partners for antimalarial therapy.
- To advocate for combination antimalarial drug use to combat resistance.
Main Methods:
- Review of existing literature on antimalarial drug resistance mechanisms.
- Analysis of the efficacy and resistance profiles of artemisinin derivatives.
- Comparison with combination therapy strategies used for tuberculosis and HIV.
Main Results:
- Artemisinin derivatives exhibit high antimalarial activity and reduce parasite biomass effectively.
- No artemisinin resistance has been reported to date.
- Combination therapy significantly lowers the probability of selecting resistant mutants.
Conclusions:
- Artemisinin derivatives are ideal partners for combination antimalarial therapy.
- Antimalarial drugs should always be used in combination, not as monotherapy.
- Combination treatments should include artemisinin or its derivatives to ensure efficacy and prevent resistance.
More Related Videos
Related Concept Videos
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
01:28Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
01:29Malaria
Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
01:15Anthelminthic Agents
Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
01:21Antiprotozoal Agents
Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...