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Clinical, Molecular, and Immunological Characteristics of Scrub Typhus in Nepal
Anurag Adhikari1,2, Carina Münch3,4, Nora En-Nosse3,4
1Department of Infection and Immunology, Kathmandu Research Institute for Biological Sciences, Lalitpur, Nepal.
Open Forum Infectious Diseases
|August 13, 2026
Abstract:
In a serologically diagnosed Nepalese scrub typhus cohort (n = 77), gastrointestinal symptoms were common. We assessed Orientia tsutsugamushi DNA in serum and performed TSA56 genotyping. Orientia DNA was detected in 10 of 77 samples (12%). TSA56 sequencing identified 4 genotypes. Polymerase chain reaction positivity was associated with diarrhea, groin lymphadenopathy, and stronger Th1-type cytokine responses.

