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Adenosine with cold blood cardioplegia during coronary revascularization
T Rinne1, J Laurikka, I Penttilä
1Department of Anaesthesia and Intensive Care, Tampere University Hospital, and Medical School, Finland.
Objective:
To investigate whether adenosine in association with blood cardioplegia results in more rapid cardiac arrest or improved myocardial protection.
Design:
A prospective, randomized, placebo-controlled double-blind clinical study.
Setting:
Operative and intensive care units in a university hospital, Finland.
Participants:
Forty patients undergoing primary, elective coronary revascularization.
Intervention:
Adenosine as a bolus dose, 12 mg intravenously, was given immediately before the induction of blood cardioplegia.
Measurements And Main Results:
There were nonsignificantly higher serial serum values of CK (MB) (p = 0.33), troponin-T (p = 0.23), and troponin-I (p = 0.10) in the adenosine group. There were no differences between the groups in arrest time, blood pressure decrease, or lactate extraction.
Conclusions:
The adenosine regimen used in this study did not cause more rapid arrest with blood cardioplegia. The effect on cardioprotection was insignificant.