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Social memory is impaired in neonatally ibotenic acid lesioned rats
1Faculty of Medicine, Otto-von-Guericke University, Institute of Pharmacology and Toxicology, Leipziger Str. 44, 39120, Magdeburg, Germany. axel.becker@medizin.uni-magdeburg.de
Abstract:
Postnatal lesion with ibotenic acid in the ventral hippocampus produces several behavioural effects that resemble the symptoms of schizophrenia. In the present study, we tested neonatally lesioned 1-year-old Sprague-Dawley rats for their social memory. It was found that social memory is worsened in lesioned rats. Subchronic treatment with haloperidol (0.025 mg/kg body weight) partly ameliorated this impairment. It was suggested that social memory might be a useful paradigm to test clinically used and potential antipsychotic drugs for their effects on learning and memory processes.