Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differentiation mechanisms and malignancy.

G I Abelev1

  • 1Institute of Carcinogenesis, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia. abelev@mx.iki.rssi.ru

Biochemistry. Biokhimiia
|March 7, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On the path to understanding the nature of cancer.

Biochemistry. Biokhimiia·2008
Same author

[The purification of the protein alternative to alfa-fetoprotein].

Vestnik Rossiiskoi akademii meditsinskikh nauk·2007
Same author

[Differentiation antigens of hemoblastoses and epithelial tumors: relations to the mechanisms of transformation and progression].

Ontogenez·2006
Same author

New approaches for the detection and characterization of alpha-fetoprotein epitope variants.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine·2003
Same author

[Differentiation antigens in tumors: dependence on carcinogenesis mechanisms and progression (a hypothesis)].

Molekuliarnaia biologiia·2003
Same author

[alpha-Fetoprotein (biology)].

Vestnik Rossiiskoi akademii meditsinskikh nauk·2001

Tumor cells retain differentiation abilities, but genetic changes can disrupt this process, leading to cancer. Inducing terminal differentiation in leukemia offers a promising therapeutic strategy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Carcinomas and hemoblastoses retain differentiation markers from normal tissues, reflecting their precursor cells' state.
  • Both tumor types possess the inherent ability to differentiate, a process influenced by genetic mechanisms.
  • Understanding differentiation is key to comprehending tumor genesis and phenotype maintenance.

Purpose of the Study:

  • To review the relationship between differentiation mechanisms and tumor phenotype.
  • To analyze oncogene activation, chimeric genes, and fused proteins in tumor development.
  • To explore the therapeutic potential of inducing terminal differentiation in specific leukemias.

Main Methods:

  • Review of T and B cell differentiation mechanisms.

Related Experiment Videos

  • Analysis of protooncogene activation via translocation to tissue-specific genes (e.g., immunoglobulin and T cell receptor genes).
  • Examination of chimeric genes and fused proteins resulting from specific translocations.

    • Main Results:

    • Protooncogene and trans-factor activation by translocation can lead to oncogenic transformation in hemoblastoses.
    • Chimeric genes and fused proteins play a role in tumor differentiation and phenotype maintenance.
    • Induction of terminal differentiation shows therapeutic promise for specific leukemias like hairy cell leukemia and promyelocytic leukemia.

    Conclusions:

    • Alterations in intercellular interactions during tumor progression stimulate growth and reduce differentiation.
    • Decreased differentiation levels can lead to re-expression of embryonic antigens in tumors.
    • Targeting differentiation mechanisms and intercellular interactions offers potential therapeutic avenues for cancer treatment.