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Liver specification and early morphogenesis.

K S Zaret1

  • 1Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. zaret@fccc.edu

Mechanisms of Development
|March 8, 2000
PubMed
Summary

Fibroblast growth factors (FGFs) signal liver development from endoderm. These FGFs induce hepatic genes and promote hepatocyte morphogenesis, crucial for early liver formation.

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Area of Science:

  • Developmental biology
  • Molecular signaling
  • Hepatogenesis

Background:

  • Liver development classically involves endoderm induction by cardiac mesoderm.
  • Fibroblast growth factors (FGFs) have recently been identified as key signaling molecules in this process.

Purpose of the Study:

  • To elucidate the role of FGFs in the initial stages of liver development (hepatogenesis).
  • To understand how FGFs regulate hepatic gene expression and cell morphogenesis.

Main Methods:

  • Analysis of hepatic gene expression in response to FGF signaling.
  • Investigation of FGF-mediated effects on hepatocyte differentiation and morphogenesis.

Main Results:

  • Multiple FGFs induce hepatic gene expression independently of growth.
  • A subset of FGFs collaborates with other factors to drive hepatocyte morphogenesis.
  • Post-liver bud formation, mesenchymal signals and hepatic pathways regulate growth, differentiation, and prevent apoptosis.

Conclusions:

  • FGF signaling is critical for the initial induction and patterning of the liver from the endoderm.
  • Understanding early hepatogenesis provides a model for endodermal tissue development.

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