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Related Experiment Videos

Roxatidine in duodenal ulcer.

C M Habibullah1, M A Habeeb, S P Singh

  • 1Dept of Gastroenterology, Osmania Medical College, Osmania General Hospital, Hyderabad.

Journal of Postgraduate Medicine
|July 1, 1995
PubMed
Summary

Roxatidine acetate, a new H2-receptor antagonist, demonstrated comparable duodenal ulcer healing rates to ranitidine. Roxatidine significantly reduced nighttime pain and showed no adverse events, offering better pain relief.

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Duodenal ulcers are common gastrointestinal conditions.
  • H2-receptor antagonists are widely used for acid suppression.

Purpose of the Study:

  • To compare the efficacy and safety of roxatidine acetate versus ranitidine in treating duodenal ulcers.
  • To evaluate the impact on ulcer healing and nocturnal pain.

Main Methods:

  • A randomized, double-blind clinical trial involving 53 patients with duodenal ulcers.
  • Patients received either roxatidine acetate (75 mg bid) or ranitidine (150 mg bid) for 4 weeks.

Main Results:

  • Comparable ulcer healing rates were observed between roxatidine acetate (22/25) and ranitidine (22/26).
  • Roxatidine acetate showed a statistically significant reduction in nighttime pain episodes (p < 0.05).
  • No adverse events were reported with roxatidine acetate treatment.

Conclusions:

  • Roxatidine acetate is as effective as ranitidine in healing duodenal ulcers.
  • Roxatidine acetate provides superior relief from nighttime pain associated with duodenal ulcers.
  • Roxatidine acetate presents a safe and effective treatment option for duodenal ulcers.

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