Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Uveitis and intraocular lenses.

M A Galin, E Chowchuvech, L Turkish

    Transactions of the Ophthalmological Societies of the United Kingdom
    |April 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Interferon and ocular viral disease.

    The Journal of general physiology·2009
    Same author

    Angle-supported refractive implantation in stable, adult accommodative esotropia.

    Strabismus·2000
    Same author

    Does laser trabeculoplasty prevent steroid glaucoma?

    Ophthalmic surgery and lasers·2000
    Same author

    A new model to assess staphylococcal adhesion to intraocular lenses under in vitro flow conditions.

    Biomaterials·1998
    Same author

    CME associated with ECCE and ICCE.

    Ophthalmic surgery·1988
    Same author

    Laser trabeculoplasty and cataract surgery.

    Transactions of the ophthalmological societies of the United Kingdom·1985

    Polymethylmethacrylate (PMMA) discs with varying unpolymerized monomer levels showed no toxicity in tissue culture or rabbit eyes. The study suggests mechanical factors, not monomer concentration, primarily cause inflammation after PMMA implantation.

    Area of Science:

    • Biomaterials Science
    • Ophthalmology
    • Toxicology

    Background:

    • Polymethylmethacrylate (PMMA) is widely used in medical implants.
    • Concerns exist regarding potential toxicity from unpolymerized monomers in PMMA devices.
    • Understanding the inflammatory response to PMMA is crucial for patient safety.

    Purpose of the Study:

    • To evaluate the toxicity of unpolymerized monomer in PMMA discs.
    • To assess the inflammatory response in ocular tissues following PMMA implantation.
    • To determine the primary cause of inflammation associated with PMMA discs.

    Main Methods:

    • PMMA discs with 0-5% unpolymerized monomer were heated to increase monomer concentration up to 3.7%.
    • In vitro studies using tissue culture were performed.

    Related Experiment Videos

  • In vivo studies involved implantation into the anterior chambers of rabbit eyes.

    • Main Results:

    • No significant toxicity was observed in tissue culture experiments.
    • No discernible difference in anterior segment response was noted across varying monomer concentrations in rabbit eyes.
    • The inflammatory response did not correlate with the concentration of unpolymerized monomer.

    Conclusions:

    • Unpolymerized monomer in PMMA discs does not appear to be toxic in ocular tissues.
    • The inflammatory response to implanted PMMA discs is likely driven by mechanical irritation rather than chemical toxicity.
    • Further investigation into the mechanical properties of PMMA implants may be warranted.