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Modeling brain compartmental lactate response to metabolic challenge: a feasibility study
S D Friedman1, S R Dager, T L Richards
1Department of Psychiatry and Behavioral Sciences, 4225 Roosevelt Way NE-Suite 306-C, University of Washington, Seattle, WA 98105-6099, USA.
Psychiatry Research
|March 10, 2000
Summary
Panic disorder (PD) patients show abnormal brain lactate responses. This study found lactate increases in PD are primarily tissue-based, not in cerebrospinal fluid (CSF), using magnetic resonance spectroscopy.
Area of Science:
- Neuroscience
- Biochemistry
- Medical Imaging
Background:
- Panic disorder (PD) is associated with abnormal brain metabolite responses.
- Magnetic resonance spectroscopy (MRS) can detect brain lactate levels.
Purpose of the Study:
- To investigate the compartmental origin of abnormal brain lactate response in panic disorder patients.
- To validate water as a stable reference signal for MRS metabolite quantification.
Main Methods:
- Integrated water quantification and tissue segmentation with MRS.
- Collected baseline and post-lactate infusion water scans for stability assessment.
- Modeled lactate changes by comparing tissue and cerebrospinal fluid (CSF) compartments.
Main Results:
- Brain water levels remained stable during lactate infusion, confirming its utility as a reference.
- Lactate increases in PD subjects were proportional to voxel tissue fraction.
- This suggests abnormal lactate accumulation is localized to brain tissue, not CSF.
Conclusions:
- The abnormal lactate response in panic disorder is tissue-based.
- MRS with water referencing allows for compartmental lactate quantification.
- This methodology is feasible for studying metabolic challenges in neurological disorders.