Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skin-prick test for severe marginal periodontitis.

S Lindskog1, O Zetterström, A Kamkar

  • 1Department of Basic Oral Sciences, School of Dentistry, Karolinska Institute, Stockholm, Sweden. Sven.Lindskog@ofa.ki.se

The International Journal of Periodontics & Restorative Dentistry
|March 10, 2000
PubMed
Summary

Treatment-resistant periodontitis patients show a reduced inflammatory response to bacterial plaque, contrary to the initial hypothesis. This suggests an impaired immune reactivity rather than an overreaction in these individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gastrin-releasing peptide receptor expression in gastrointestinal stromal tumours.

ESMO gastrointestinal oncology·2026
Same author

Image of an adrenal mesenchymoma.

ANZ journal of surgery·2023
Same author

Longitudinal Doppler Assessments in Late Preterm Fetal Growth Restriction.

Ultraschall in der Medizin (Stuttgart, Germany : 1980)·2021
Same author

Fetal cerebral Doppler changes and outcome in late preterm fetal growth restriction: prospective cohort study.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2020
Same author

Fishes in a changing world: learning from the past to promote sustainability of fish populations.

Journal of fish biology·2018
Same author

Utility of single versus multiple breath washout in adult asthma.

Clinical physiology and functional imaging·2018

Area of Science:

  • Periodontology
  • Immunology

Background:

  • Periodontitis is a common inflammatory disease affecting the gums.
  • Treatment resistance in periodontitis suggests complex underlying mechanisms.
  • Inflammatory responses are key to understanding disease progression and treatment outcomes.

Purpose of the Study:

  • To investigate the inflammatory response in treatment-resistant periodontitis patients.
  • To test the hypothesis of an inflammatory overreaction in resistant cases.
  • To compare immune reactivity to bacterial plaque components between different patient groups.

Main Methods:

  • Skin-prick testing with lipid A was performed on patients with severe periodontitis (Gingival Index > 20%) who were resistant to treatment.
  • Control groups included periodontitis patients who responded to treatment and healthy individuals.

Related Experiment Videos

  • Inflammatory reactivity was assessed based on skin test responses.

    • Main Results:

    • Patients with treatment-resistant periodontitis exhibited minimal positive skin-prick test responses to lipid A.
    • This response was significantly lower compared to periodontitis patients who responded to treatment and healthy controls.
    • The findings indicate a diminished inflammatory reactivity in treatment-resistant periodontitis.

    Conclusions:

    • The hypothesis of an inflammatory overreaction in treatment-resistant periodontitis was rejected.
    • Impaired inflammatory reactivity to periodontitis pathogens may characterize treatment-resistant cases.
    • Further research into immune mechanisms is warranted for understanding and managing resistant periodontitis.