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Melatonin treatment of winter depression: a pilot study
A J Lewy1, V K Bauer, N L Cutler
1Department of Psychiatry, Oregon Health Sciences University, Portland 97201-3098, USA. lewy@ohsu.edu
Psychiatry Research
|March 10, 2000
Abstract:
Five patients with winter depression received low doses of melatonin in the afternoon, and five patients received placebo capsules. Melatonin treatment significantly decreased depression ratings compared to placebo. If these findings are replicated in a larger sample with documentation of expected phase shifts, the phase shift hypothesis will be substantially supported.