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Updated: Aug 10, 2026
Transretinal ERG Recordings from Mouse Retina: Rod and Cone Photoresponses
Published on: March 14, 2012
Cone properties of the light-adapted murine ERG
B Ekesten1, P Gouras, M Moschos
1Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala. bjorn.ekesten@kirmed.slu.se
Purpose:
Because the mouse lacks a typical Purkinje shift, we have examined its light-adapted ERG to determine whether there was other evidence in addition to tolerance to background light, that could be used to identify cone function in the ERG.
Methods:
Full field corneal ERGs to white flashes, double flashes and flash trains were examined in the presence of a strong full field light adaptation and compared with the human cone ERG.
Results:
The following cone-like properties could be identified. (1) The light-adapted murine ERG increases in amplitude gradually during the first 10 minutes of light-adaptation; (2) It is capable of responding to a 50 Hz stimulus, although its overall frequency response is slower than that of the human cone ERG; (3) A corneal positive d-wave occurs to the termination of a flash train; (4) The response increases linearly with light intensity.
Conclusion:
The light-adapted murine ERG has several properties of cones but it has a slower response than the human cone ERG.
