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Updated: Jun 24, 2026
13:17
Microarray Analysis for Saccharomyces cerevisiae
Published on: April 7, 2011
SURVEY AND SUMMARY: Saccharomyces cerevisiae basic helix-loop-helix proteins regulate diverse biological processes
1Department of Molecular and Cellular Biochemistry, Loyola University of Chicago, Maywood, IL 60153, USA.
Nucleic Acids Research
|March 10, 2000
Summary
This review summarizes basic helix-loop-helix (bHLH) protein functions in yeast. We explore how these regulatory proteins dimerize and bind DNA to control various biological pathways, leveraging genomic data.
Area of Science:
- Molecular Biology
- Genetics
- Yeast Biology
Background:
- Basic helix-loop-helix (bHLH) proteins are crucial eukaryotic regulators.
- Their HLH domain facilitates dimerization, forming homo- and heterodimers.
- Dimerization enables DNA binding to the E-box (5'-CANNTG-3') via basic regions.
Purpose of the Study:
- To review current knowledge on bHLH protein function in Saccharomyces cerevisiae.
- To highlight the importance of bHLH proteins in regulating diverse yeast biological pathways.
Main Methods:
- Review of existing literature on yeast bHLH proteins.
- Integration of traditional genetic methodologies with whole-genome expression studies.
- Analysis of bHLH protein roles in Saccharomyces cerevisiae.
Main Results:
- Several bHLH proteins have been identified in yeast through genetic studies.
- These proteins are involved in regulating a wide array of biological processes.
- Genomic and expression data offer new avenues for functional studies.
Conclusions:
- Yeast bHLH proteins play significant roles in cellular regulation.
- The combination of genomic data and advanced methodologies enhances understanding of bHLH functions.
- Further research on yeast bHLH proteins is warranted to fully elucidate their regulatory networks.
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