Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gamete-competition models.

J S Sinsheimer1, J Blangero, K Lange

  • 1Department of Biomathematics, UCLA School of Medicine, Los Angeles, CA, 90095, USA. janet@sunlab.ph.ucla.edu

American Journal of Human Genetics
|March 11, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential gene expression study in whole blood identifies candidate genes for psychosis in African American individuals.

Schizophrenia research·2025
Same author

Publisher Correction: Brain charts for the human lifespan.

Nature·2022
Same author

Brain charts for the human lifespan.

Nature·2022
Same author

Genetic differentiation between baboon subspecies: Relevance for biomedical research.

American journal of primatology·2020
Same author

Genetic structure of three populations of rhesus macaques (Macaca mulatta): Implications for genetic management.

American journal of primatology·2020
Same author

Assessing the effects of candidate genes on quantitative traits in primate populations.

American journal of primatology·2020
Same journal

Bi-allelic missense variants in human GPN2 result in Perrault syndrome.

American journal of human genetics·2026
Same journal

Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes.

American journal of human genetics·2026
Same journal

A transparent and generalizable deep-learning framework for genomic ancestry prediction.

American journal of human genetics·2026
Same journal

Data-driven RNA phenotyping captures genetically regulated dimensions of the transcriptome.

American journal of human genetics·2026
Same journal

Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans.

American journal of human genetics·2026
Same journal

Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns.

American journal of human genetics·2026
See all related articles

The gamete-competition model analyzes genetic transmission, extending the Bradley-Terry model. It estimates allele transmission probabilities and detects segregation distortion using pedigree data, incorporating covariates for complex genetic analyses.

Area of Science:

  • Genetics
  • Statistical Genetics
  • Population Genetics

Background:

  • The Bradley-Terry model is used for ranking sports teams.
  • Mendelian segregation assumes equal transmission probabilities for alleles.
  • Existing methods for segregation analysis may not fully capture transmission dynamics.

Purpose of the Study:

  • To introduce and evaluate the gamete-competition model for genetic segregation analysis.
  • To extend the transmission/disequilibrium test using full pedigree data.
  • To incorporate covariates into segregation analysis for a more nuanced understanding of allele transmission.

Main Methods:

  • Application of the gamete-competition model, a variant of the Bradley-Terry model.
  • Estimation of allele transmission parameters (tau_i) from pedigree data.

Related Experiment Videos

  • Likelihood-ratio tests to assess deviations from Mendelian segregation.
  • Incorporation of covariates using exponential parameterization (tau_i = exp(beta*x_k)).

    • Main Results:

    • The model provides estimates of allele transmission probabilities.
    • It allows for the detection and quantification of transmission distortion.
    • Covariates such as child's sex or disease severity can be integrated into the analysis.

    Conclusions:

    • The gamete-competition model offers a powerful framework for segregation analysis.
    • It generalizes the transmission/disequilibrium test and accommodates quantitative/qualitative outcomes.
    • The model facilitates the study of allele transmission distortion in the presence of covariates.