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Related Experiment Videos

Photosensitivity in lupus.

T P Millard1, J L Hawk, J M McGregor

  • 1Department of Photobiology, St John's Institute of Dermatology, St Thomas' Hospital, London, UK. thomas.millard@kcl.ac.uk

Lupus
|March 14, 2000
PubMed
Summary
This summary is machine-generated.

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Patients with lupus erythematosus (LE) can experience abnormal skin reactions to ultraviolet radiation (UVR), known as photosensitivity. This review details various forms of LE photosensitivity and management strategies.

Area of Science:

  • Dermatology
  • Immunology
  • Photobiology

Background:

  • Lupus erythematosus (LE) encompasses a range of skin conditions, categorized into LE-specific skin disease, non-specific cutaneous manifestations, and drug-induced complications.
  • Photosensitivity, an abnormal skin response to ultraviolet radiation (UVR), is a notable feature in LE, particularly in cutaneous forms and systemic lupus erythematosus (SLE).

Purpose of the Study:

  • To review the clinical presentation and management of photosensitivity in patients with lupus erythematosus.
  • To differentiate between LE-specific photosensitivity, drug-induced phototoxic reactions, and other photosensitive disorders associated with LE.

Main Methods:

  • Review of clinical presentations of photosensitivity in lupus erythematosus.
  • Examination of UVR-induced or exacerbated skin lesions in LE.

Related Experiment Videos

  • Discussion of phototoxic reactions from photosensitizing medications.
  • Consideration of rare associations like porphyria cutanea tarda, solar urticaria, and erythropoietic protoporphyria (EPP).

    • Main Results:

    • Abnormal photosensitivity in LE manifests in various ways, including UVR-induced or exacerbated lesions in LE-specific skin disease.
    • Phototoxic reactions, often presenting as exaggerated sunburn, can occur in patients taking photosensitizing drugs.
    • Rarely, photosensitivity may present as fragile skin and blistering, sometimes associated with porphyria cutanea tarda.

    Conclusions:

    • Photosensitivity is a significant clinical issue in lupus erythematosus, requiring careful assessment through history and examination.
    • Phototesting is rarely needed for diagnosis; management focuses on patient education regarding sun avoidance, photoprotection, and sunscreen use.