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Deoxycorticosterone hypertension in the pig
Clinical Science and Molecular Medicine. Supplement
|December 11, 1976
Summary
Deoxycorticosterone acetate (DOCA) induced hypertension in pigs, primarily through increased total peripheral resistance. This model reveals functional and structural vascular changes contributing to sustained high blood pressure.
Area of Science:
- Cardiovascular Physiology
- Endocrinology
Background:
- Deoxycorticosterone acetate (DOCA) is a steroid hormone involved in regulating blood pressure.
- Understanding the mechanisms of DOCA-induced hypertension is crucial for cardiovascular research.
Purpose of the Study:
- To investigate the physiological and vascular changes associated with DOCA-induced hypertension in pigs.
- To determine the role of total peripheral resistance in DOCA-induced hypertension.
Main Methods:
- DOCA implantation in pigs to induce hypertension.
- Measurement of mean arterial pressure, serum hormone levels (DOCA, aldosterone, renin), and electrolytes.
- Assessment of vascular reactivity to noradrenaline and angiotensin.
- Analysis of hind-limb vascular bed function and structure in isolated preparations.
Main Results:
- DOCA implantation led to sustained hypertension (140-160 mmHg) within a month, mainly due to increased total peripheral resistance.
- DOCA levels remained elevated for 90 days; aldosterone decreased, and hypokalemia and suppressed plasma renin activity were observed.
- Hypertensive pigs showed increased sensitivity to noradrenaline and angiotensin, with both functional and structural alterations in vascular beds.
Conclusions:
- DOCA-induced hypertension in pigs is characterized by increased total peripheral resistance and altered vascular smooth muscle sensitivity.
- Both functional and structural vascular changes contribute to sustained hypertension, with functional changes persisting even when structural alterations are prevented.