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[Allergy to macrolides. 21 cases].

P Demoly1, S Benahmed, H Sahla

  • 1Maladies respiratoires, Hôpital Amaud de Villeneuve, Montpellier. demoly@montp.inserm.fr

Presse Medicale (Paris, France : 1983)
|March 17, 2000
PubMed
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Most hypersensitivity reactions to macrolides are rare. Provocation tests are the most reliable diagnostic method for identifying true macrolide allergies, as confirmed by skin tests in a small patient group.

Area of Science:

  • Pharmacology
  • Immunology
  • Clinical Medicine

Context:

  • Allergic drug reactions to macrolides are uncommon.
  • Limited data exists on diagnostic methods for macrolide hypersensitivity.
  • Urticaria is a common presentation of suspected macrolide allergy.

Purpose:

  • To evaluate diagnostic tests for macrolide hypersensitivity.
  • To determine the efficacy of skin tests and provocation tests in diagnosing macrolide allergy.

Summary:

  • Twenty-one patients with suspected macrolide allergies underwent skin tests (prick and intradermal) with spiramycin and erythromycin.
  • Seventeen patients were subjected to controlled provocation tests.
  • Only three patients demonstrated true allergy to spiromycin, confirmed by positive provocation and skin tests.

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Impact:

  • Provocation tests are crucial for diagnosing macrolide hypersensitivity.
  • This study highlights the low incidence of true macrolide allergy.
  • Findings aid clinicians in managing suspected macrolide drug reactions.