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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
[Allergy to macrolides. 21 cases]
P Demoly1, S Benahmed, H Sahla
1Maladies respiratoires, Hôpital Amaud de Villeneuve, Montpellier. demoly@montp.inserm.fr
Objective:
Allergic drug reactions to macrolides are extremely rare and there is little information in the literature concerning relevant diagnostic tests.
Patients And Methods:
Twenty-one patients were recently seen for assumed allergies (principally urticaria) to diverse macrolides. Skin tests (prick and intradermal tests) were performed with injectable forms of spiramycin and erythromycin. Seventeen out of 21 patients were provoked under strict hospital surveillance.
Results:
Only 3 patients had a positive provocation test and were thus truly allergic (to spiromycin). They had positive skin tests to both macrolides tested.
Conclusion:
Most hypersensitivity reactions to macrolides are therefore diagnosed with provocation tests.
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