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Polymorphism of NACP-Rep1 in Parkinson's disease: an etiologic link with essential tremor?
E K Tan1, T Matsuura, S Nagamitsu
1Department of Neurology, Baylor College of Medicine, Houston 77030, USA.
Neurology
|March 17, 2000
Abstract:
An allele (263bp) of the nonamyloid component of plaques (NACP)-Repl polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD) patients. Allele 263bp was significantly higher in PD patients (OR = 3.86) and ET patients (OR = 6.42) but not HD patients, compared with healthy controls. The association of allele 263bp with PD and ET suggests a possible etiologic link between these two conditions.