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Updated: Oct 17, 2026

Point of Care Transcranial Color-Coded Duplex Ultrasound of the Middle Cerebral Artery
Published on: August 9, 2024
[Usefulness of Doppler echocardiography in patients with ischemic cerebrovascular disease]
1Department of Neurosurgery, Shioya General Hospital, Japan.
Insights
Transthoracic Doppler echocardiography revealed higher mitral regurgitation in ischemic cerebrovascular disease patients. Diastolic dysfunction, indicated by a lower E/A ratio, was also prevalent, suggesting cardiac involvement.
Area of Science:
- Cardiology
- Neurology
- Medical Imaging
Background:
- Ischemic cerebrovascular disease (ICVD) is often associated with cardiovascular abnormalities.
- Understanding cardiac function in ICVD patients is crucial for comprehensive patient management.
Purpose of the Study:
- To evaluate cardiac function, including valvular regurgitation and diastolic function, in patients with ICVD using transthoracic Doppler echocardiography.
- To investigate the relationship between ICVD and specific cardiac parameters.
Main Methods:
- Transthoracic Doppler echocardiography was performed on 213 patients diagnosed with ICVD.
- Key parameters assessed included valvular regurgitation (mitral, tricuspid), left ventricular diastolic function (E/A ratio), and ejection fraction (EF).
- Data were compared between ICVD patients and a control group.
Main Results:
- Patients with embolic strokes showed a significantly higher prevalence of left ventricular valvular regurgitation, particularly mitral regurgitation, compared to controls.
- No significant difference in right ventricular valvular regurgitation was observed between groups.
- A significantly lower E/A ratio was found in ICVD patients, indicating diastolic dysfunction, despite no significant difference in ejection fraction.
- ICVD patients exhibited a tendency towards systemic atherosclerotic changes, correlating with impaired cardiac wall compliance and diastolic dysfunction.
Conclusions:
- Transthoracic Doppler echocardiography is a valuable tool for assessing cardiac diastolic dysfunction and valvular regurgitation in patients with ischemic cerebrovascular disease.
- The findings highlight the significant cardiac implications of ICVD, particularly concerning left-sided heart valves and diastolic function.
Abstract:
We carried out transthoracic Doppler echocardiography on 213 patients with ischemic cerebrovascular disease to examine cardiac functions. The prevalence of valvular regurgitation, left ventricular diastolic function (E/A ratio), and ejection fraction (EF) of each patient were studied by transthoracic Doppler echocardiography. In patients with embolic strokes, the prevalence of valvular regurgitation of the left ventricular system such as mitral regurgitation was significantly higher than that of normal controls. In contrast, there was no significant difference in the prevalence of valvular regurgitation in the right ventricular system. Although there was no significant difference in the ejection fraction between groups, the E/A ratio in patients with ischemic cerebrovascular disease showed a significantly lower value than that in normal controls. Patients with ischemic cerebrovascular disease showed a tendency to have an atherosclerotic change in the systemic arteries including cerebral and coronary arteries, reflecting an aggravation of cardiac wall compliance and diastolic dysfunction resulting in lowering of the E/A ratio. Thus, transthoracic Doppler echocardiography was useful to evaluate cardiac diastolic dysfunction and valvular regurgitation in patients with ischemic cerebrovascular disease.
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