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Updated: Jan 27, 2026
Coronary Artery Disease IV: Preventive Measures
Published on: June 19, 2025
Coronary physiology revisited : practical insights from the cardiac catheterization laboratory
1Department of Internal Medicine, Division of Cardiology, Saint Louis University Health Sciences Center, St. Louis, MO 63110, USA. kernm@slu.edu
Abstract:
Various coronary physiological measurements can be made in the cardiac catheterization laboratory using sensor-tipped guidewires; they include the measurement of poststenotic absolute coronary flow reserve, the relative coronary flow reserve, and the pressure-derived fractional flow reserve of the myocardium. Ambiguity regarding abnormal microcirculation has been reduced or eliminated with measurements of relative coronary flow reserve and fractional flow reserve. The role of microvascular flow impairment can be separately determined with coronary flow velocity reserve measurements. In addition to lesion assessment before and after intervention, emerging applications of coronary physiology include the determination of physiological responses to new pharmacological agents, such as glycoprotein IIb/IIIa blockers, in patients with acute myocardial infarction. Measurements of coronary physiology in the catheterization laboratory provide objective data that complement angiography for clinical decision-making.
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