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LC assay method for oxfendazole and oxyclozanide in pharmaceutical preparation
A R Khan1, M J Akhtar, R Mahmood
1Research and Development Laboratory, S.I.T.E., Glaxowellome Pakistan Limited, Karachi.
Journal of Pharmaceutical and Biomedical Analysis
|March 22, 2000
Abstract:
A method has been developed for the simultaneous determination of oxfendazole and oxyclozanide in a pharmaceutical preparation. The method involves reversed phase chromatography with isocratic elution of the mobile phase and detection at 300 nm. The range of quantification for oxfendazole and oxyclozanide was found to be 2-7 microg ml(-1) and 3-10 microg ml(-1), respectively. The validity of the method was evaluated in terms of linear regression analysis, precision, specificity and accuracy.