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Updated: Jul 22, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Treatment of severe atopic dermatitis by topical immune modulation using dinitrochlorobenzene
L B Mills1, L J Mordan, H L Roth
1Department of Dermatology, The Honolulu Medical Group, Inc, Honolulu, USA. lmills@pixi.com
Abstract:
We present the results of a small uncontrolled pilot trial which suggest that contact sensitization to dinitrochlorobenzene and repeated weekly applications significantly improve the clinical status of severe atopic dermatitis in adults. Although no changes were noted in circulating levels of either lymphocyte subset populations or the serum cytokines assayed in this trial, our observations may be due to topical immune modulation by dinitrochlorobenzene. Larger controlled studies of dinitrochlorobenzene treatment in atopic dermatitis are warranted.
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