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Intracellular calcium releases facilitate induction of long-term depression
1Department of Integrative Brain Science, Kyoto University Graduate School of Medicine, 606-8501, Kyoto, Japan. f50207@sakura.kudpc.kyoto-u.ac.jp
Neuropharmacology
|March 23, 2000
Abstract:
In visual cortex layer II/III pyramidal neurons, long-term depression (LTD) of synaptic currents was induced by a combination of the intracellular increase of inositol-1,4,5-trisphosphate (IP(3)), achieved by photolyzing caged-IP(3), and the tetanization to nearby cortex, but not by either of these two procedures alone. A facilitatory role of an IP(3)-induced calcium release in LTD is suggested.