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A phytochemical investigation of Alchornea latifolia
W N Setzer1, X Shen, R B Bates
1Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA. wsetzer@matsci.uah.edu
Fitoterapia
|March 23, 2000
Abstract:
A phytochemical investigation of the chloroform leaf extract of Alchornea latifolia has been undertaken. Along with the triterpenoids taraxerone, friedelin, epifriedelinol, and taraxerol, the plant also contains seco-3,4-friedelin (dihydroputranjivic acid) (1) and seco-3,4-taraxerone (2). These A-ring-opened triterpenoids show in vitro cytotoxic activity against Hep-G2 and A-431 human cancer cell lines and are potent inhibitors of topoisomerase II.

