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Control of Sindbis virus infection by antibody in interferon-deficient mice
A P Byrnes1, J E Durbin, D E Griffin
1Department of Molecular Microbiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA.
Journal of Virology
|March 23, 2000
Abstract:
Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon. Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.

