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Flipping the oncogene switch: illumination of tumor maintenance and regression

L Chin1, R A DePinho

  • 1Departments of Adult Oncology, Dana Farber Cancer Institute, Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA. lynda_chin@dfci.harvard.edu

Trends in Genetics : TIG
|March 24, 2000
PubMed

Insights

Inducible cancer models in mice allow scientists to study oncogene roles in established tumors. This research helps understand tumor-host interactions and predict responses to targeted cancer therapies.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Understanding oncogene roles is crucial for cancer research.
  • Developing models to study established tumors is challenging.

Purpose of the Study:

  • To investigate the function of oncogenes in maintaining established tumors.
  • To explore host-tumor symbiosis in cancer development.
  • To predict tumor response to targeted therapies.

Main Methods:

  • Genetic engineering of cancer-prone mice.
  • Inducible control of transgene expression in vivo.
  • Analysis of oncogenic signals and tumor biology.

Main Results:

  • Demonstrated the utility of inducible cancer models.
  • Provided insights into host-tumor interactions.
  • Established a framework for predicting therapy responses.

Conclusions:

  • Inducible cancer models are valuable tools for cancer research.
  • These models facilitate the study of oncogene functions in established tumors.
  • The approach aids in predicting biological responses to cancer therapies.

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