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A structure-activity study of a C-terminal endothelin analogue

E Cassano1, C Galoppini, L Giusti

  • 1Istituto di Mutagenesi e Differenziamento, CNR, Laboratorio Sintesi Peptidica, Pisa, Italy.

Folia Biologica
|March 24, 2000
PubMed
Summary

Structure-activity studies of endothelin (ET) analogues reveal that the C-terminal Ile-Trp residues are crucial for receptor subtype activity. Modifications in the central peptide region showed greater tolerance, offering insights into ET analogue design.

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