Related Experiment Video
Updated: Jul 30, 2026
07:33
Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs
Published on: July 6, 2015
Methyl bromide 1-year dietary study in dogs
N H Wilson1, P E Newton, M Rahn
1Experimental Pathology Laboratories, Inc., Bowman Gray Technical Center, Winston-Salem, NC 27102, USA.
Summary
Methyl bromide (MB) is a fumigant used on food. A one-year dog study found no observed adverse effects at doses approximately 200 times higher than average human dietary exposure to MB.
Area of Science:
- Toxicology
- Food Safety
- Environmental Health
Context:
- Methyl bromide (MB) is a widely used fumigant in food production.
- Assessing potential health risks associated with dietary exposure to MB residues is crucial.
- Previous estimations placed average human dietary exposure at 0.00125 mg/kg/day.
Purpose:
- To evaluate the safety of methyl bromide (MB) residues in food through a long-term animal study.
- To determine the no-observed-effect level (NOEL) for MB in a mammalian model.
- To compare canine exposure levels with estimated human dietary intake.
Summary:
- A one-year feeding study exposed beagle dogs to diets fumigated with methyl bromide (MB) at varying doses.
- Dose levels were designed to achieve exposure at least 100 times the average human dietary intake.
- Comprehensive clinical, pathological, and physiological assessments revealed no significant differences between control and MB-treated groups.
Impact:
- The study established a no-observed-effect level (NOEL) for MB of at least 0.28 mg/kg/day in dogs.
- This NOEL is approximately 200 times greater than the estimated average human dietary exposure.
- Findings support the safety of current dietary exposure levels to MB residues in food.
