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Decreased deiminated keratin K1 in psoriatic hyperproliferative epidermis
A Ishida-Yamamoto1, T Senshu, H Takahashi
1Department of Dermatology, Asahikawa Medical College, Asahikawa, Japan.
The Journal of Investigative Dermatology
|March 25, 2000
Summary
Deiminated proteins, primarily keratin K1, are reduced in psoriatic skin lesions. This abnormal keratin deimination is specific to hyperproliferative psoriatic epidermis, sparing sweat duct epithelia.
Area of Science:
- Biochemistry
- Dermatology
- Cell Biology
Background:
- Citrulline-containing proteins, derived from deiminated arginine residues, are present in the cornified layers of human epidermis.
- These proteins, particularly keratin K1, play a role in epidermal structure and function.
Purpose of the Study:
- To investigate the localization and characteristics of deiminated proteins in psoriatic epidermis.
- To determine if altered deimination of keratin K1 is associated with psoriasis.
Main Methods:
- Immunostaining using antibodies specific to citrulline residues and keratin K1.
- Analysis of keratin expression in normal, uninvolved psoriatic, and involved psoriatic epidermis.
- Double staining to correlate deiminated K1 with suprabasal keratin expression.
Main Results:
- Normal and uninvolved psoriatic epidermis showed diffuse deiminated proteins in the cornified layer.
- Involved psoriatic epidermis exhibited markedly reduced or undetectable levels of deiminated proteins, including keratin K1.
- Deiminated K1 was absent in psoriatic lesions but present in acrosyringia, despite reduced suprabasal keratin in both.
Conclusions:
- Abnormal keratin deimination is a feature of hyperproliferative psoriatic epidermis.
- The deimination process is specifically altered in psoriatic lesions, not affecting sweat duct epithelia.
- Reduced deiminated K1 may be linked to the altered keratinization observed in psoriasis.