Related Experiment Video

Updated: Aug 11, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Sensory neurons shape γδ T cell effector programs to control psoriasiform inflammation

Juan M Inclan-Rico1, Camila M Napuri2, Adriana Stephenson2

  • 1Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

The Journal of Investigative Dermatology
|August 4, 2026
PubMed
Summary

Sensory neurons, specifically NP1, can suppress psoriasis by reducing inflammatory cells. Conversely, NP2 activation worsens the condition, highlighting distinct roles for these nerve subsets in skin immunity.

Keywords:
ItchNeuroimmunologyPeripheral Nervous SystemPsoriasisT cells

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