[Changes in epidemiological pattern of methicillin-resistant Staphylococcus aureus infections in a tertiary hospital.

M S Corbacho Malo1, J Sarria Amigot, M J Hernández Navarrete

  • 1Servicio de Medicina Preventiva, Hospital Miguel Servet, Zaragoza. msolcorb@public.ibercaja.es

Medicina Clinica
|March 29, 2000
PubMed
Abstract

Insights

This study tracked Methicillin-resistant Staphylococcus aureus (MRSA) infections from 1992-1997. Findings indicate a rise in MRSA cases among elderly patients and within medical services.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Medical Microbiology

Context:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant healthcare challenge.
  • Understanding MRSA infection trends is crucial for effective public health strategies.
  • Surveillance of MRSA in tertiary-care settings provides valuable epidemiological data.

Purpose:

  • To delineate the demographic patterns of MRSA infections.
  • To identify trends in MRSA infections between 1992 and 1997.
  • To analyze the distribution of MRSA across different hospital services.

Summary:

  • A descriptive study analyzed 267 MRSA infections in a tertiary-care hospital.
  • Internal Medicine, Urology, Neurology, Vascular Surgery, and ICUs were most affected.
  • An increasing trend was observed in patients over 65 and in medical services.

Impact:

  • The findings highlight a potential increase in community-based MRSA carriage among the elderly.
  • This data can inform targeted interventions for vulnerable populations.
  • Understanding service-specific infection rates aids in resource allocation and infection control.

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...