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[Heat stroke: pathophysiology and pathogenesis]
1Afd. Algemene Interne Geneeskunde, Leids Universitair Medisch Centrum, Leiden.
The pathophysiology of heat stroke is not fully understood. Endotoxins and cytokines appear to play a major part in the central nervous system and in the peripheral tissues. Use of specific receptor blockers prior to heat exposure can diminish cerebral damage in animal experiments. The energy depletion model of Hubbard gives a possible explanation for the rhabdomyolysis observed in some heat stroke patients. Failure of the ATP dependent Na(+)-K+ pump is essential in this theory.
The pathophysiology of heat stroke is not fully understood. Endotoxins and cytokines appear to play a major part in the central nervous system and in the peripheral tissues. Use of specific receptor blockers prior to heat exposure can diminish cerebral damage in animal experiments. The energy depletion model of Hubbard gives a possible explanation for the rhabdomyolysis observed in some heat stroke patients. Failure of the ATP dependent Na(+)-K+ pump is essential in this theory.