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Immature B cells in bone marrow express Fas/FasL
N Nilsson1, S Ingvarsson, C A Borrebaeck
1Department of Immunotechnology, Lund University, Lund, Sweden.
Scandinavian Journal of Immunology
|March 29, 2000
Summary
Negative selection eliminates autoreactive lymphocytes. Researchers found Fas and FasL in human bone marrow B cells, suggesting a mechanism for eliminating self-reactive B cells during development.
Area of Science:
- Immunology
- Cell Biology
- Developmental Biology
Background:
- Negative selection is crucial for removing self-reactive lymphocytes.
- Mechanisms of B lymphocyte negative selection in human bone marrow are not well understood.
Purpose of the Study:
- To investigate the role of the Fas (APO-1/CD95) system in human bone marrow B cell negative selection.
Main Methods:
- Analysis of human bone marrow cells.
- Detection of Fas and Fas ligand (FasL) expression on immature B lymphocytes.
Main Results:
- Fas was expressed on immature B lymphocytes (CD10/CD19+/CD40+/sIg+).
- FasL was present on CD19+ bone marrow cells.
Conclusions:
- The expression of Fas and FasL suggests a potential mechanism for the negative selection of autoreactive B cells in the human bone marrow.