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Determination of formaldehyde in liquid, solid and semisolid pharmaceuticals and cosmetics by flow
L Gámiz-Gracia1, M D Luque de Castro
1Analytical Chemistry Division, Faculty of Sciences, University of Córdoba, Spain.
The Analyst
|March 29, 2000
Abstract:
A spectrophotometric method is proposed for the determination of formaldehyde in liquid, solid and semisolid cosmetic and pharmaceutical samples, employing, for the first time in this field, the coupling of a continuous flow configuration to a pervaporation unit. The method is based on the reaction of the analyte with pararosaniline in acidic medium and subsequent formation of a coloured product (alkylsulfonic acid chromophore) with sodium sulfite, which was monitored spectrophotometrically. The method was applied to samples in which the formaldehyde content is regulated by law.